Arkansas' Blanche Lincoln is in a senate runoff against union-backed democrat Bill Halter. Polls show she could become the 5th incumbent this year to lose her seat. "Essentially if you have anything to do with Washington, you better watch your back," said political analyst Mark Murray.
That's the feeling, fueled by tea party candidates like Nevada's Sharron Angle who's hoping to face Harry Reid in the fall. Analysts say a tea party win could actually help Reid.
Next door in California, governor and senate races are hot with two female CEO's on the republican ticket.
Carly Fiorina is hoping to unseat senator Barbara Boxer. Former eBay chief Meg Whitman's facing democrat Steve Poizner for governor in California, where budget cuts threaten schools.
South Carolina's got four republicans running for governor, including Nikki Haley, who could become the state's first Indian-American in that office.
And all of today's races are leading to the big question in Washington: will democrats be able to hold onto their majority in November?